Solid‐State Radical C−H Trifluoromethylation Reactions Using Ball Milling and Piezoelectric Materials
Yadong Pang, Joo Won Lee, Koji Kubota, Hajime Ito
Abstract
Abstract The application of piezoelectricity for the generation of trifluoromethyl (CF 3 ) radicals is reported together with the development of a method for the mechanochemical C−H trifluoromethylation of aromatic compounds. As compared to conventional solution‐based approaches, this mechanoredox C−H trifluoromethylation enables cleaner and more sustainable access to a wide range of trifluoromethylated N‐heterocycles and peptides, which are important structural motifs in modern drug discovery. This study thus represents an important milestone for future applications of mechanoredox systems to medicinal and pharmaceutical science.
Topics & Concepts
TrifluoromethylationMechanochemistryRadicalChemistryBall millTrifluoromethylPiezoelectricityCombinatorial chemistryNanotechnologyOrganic chemistryMaterials scienceMetallurgyComposite materialAlkylFluorine in Organic ChemistryInorganic Fluorides and Related CompoundsRadical Photochemical Reactions