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Reduction of the therapeutic dose of silencing RNA by packaging it in extracellular vesicles via a pre-microRNA backbone

Ryan Reshke, James A. Taylor, Alexandre Savard, Hui‐Shan Guo, Luke H. Rhym, Piotr S. Kowalski, My Tran Trung, Charles Campbell, Wheaton Little, Daniel G. Anderson, Derrick Gibbings

2020Nature Biomedical Engineering159 citationsDOIOpen Access PDF

Topics & Concepts

Small interfering RNADicerGene silencingmicroRNARNA interferenceRNACell biologyExtracellular vesicleSmall RNAExtracellularMicrovesiclesCytoplasmChemistryBiologyMolecular biologyBiochemistryGeneRNA Interference and Gene DeliveryExtracellular vesicles in diseaseMicroRNA in disease regulation
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