Uncovering specificity of endogenous TAU aggregation in a human iPSC-neuron TAU seeding model
Justine D. Manos, Christina N Preiss, Nandini Venkat, Joseph A. Tamm, Peter Reinhardt, Taekyung Kwon, Jessica Wu, Allison D. Winter, Thomas R. Jahn, Kiran Yanamandra, Katherine Titterton, Eric Karran, Xavier Langlois
Abstract
model presented here represents the first successful demonstration of combining human neurons, endogenous tau expression, and AD brain-derived competent tau species, offering a more physiologically relevant platform to study tau pathobiology.
Topics & Concepts
EndogenyNeuroscienceTau proteinInduced pluripotent stem cellTau pathologyMutantIn vitroNeuronHuman brainBiologyFibrilCell biologyChemistryAlzheimer's diseaseBiophysicsBiochemistryDiseaseMedicineEmbryonic stem cellPathologyGeneAlzheimer's disease research and treatmentsNeuroscience and Neural EngineeringPluripotent Stem Cells Research