Exosomes' function in cardiovascular protection and neovascularization implies that they might be used to treat ischemia and atherosclerotic cardiovascular diseases
Moataz Dowaidar
Abstract
Myocardial hypertrophy, injury and infarction, ventricular remodeling, angiogenesis, and atherosclerosis are all influenced by cardiac exosome proteins and miRNAs, which mediate cell-to-cell communication, stimulate or inhibit target cell activities, and have an impact on myocardial hypertrophy, injury and infarction, ventricular remodeling, angiogenesis, and atherosclerosis. Circulating cardiac-specific exosome microRNAs show potential as biomarkers for early identification of acute myocardial infarction and as prognostic indicators for ischemic cardiomyopathy and congestive heart failure progression. Exosomes' function in cardiovascular protection and neovascularization implies that they might be used to treat ischemia and atherosclerotic cardiovascular diseases. Because of their biocompatibility, circulatory stability, biological barrier penetration, limited immunogenicity, and low toxicity, exosomes have the potential to deliver therapeutic pharmacologic compounds.A greater understanding of exosome composition and activity will facilitate the development of novel therapeutic alternatives for the treatment of patients with atherosclerotic cardiovascular diseases.