Alzheimer Dementia in People Living With HIV
Andrea Calcagno, Luigi Celani, Mattia Trunfio, Giancarlo Orofino, Daniele Imperiale, Cristiana Atzori, Vincenzo Arena, Gabriella d'Ettorre, Giovanni Guaraldi, Magnus Gisslen, Giovanni Di Perri
Abstract
OBJECTIVE: Given the aging of people living with HIV (PLWH) and the high prevalence of HIV-associated neurocognitive disorders, we aimed at describing the clinical, instrumental, and CSF features of PLWH diagnosed with Alzheimer dementia (AD). METHODS: The databases of 3 large Italian outpatient clinics taking care of more than 9,000 PLWH were searched for the diagnosis of AD. After obtaining patients' or their next of kin's consent for publication, anonymous data were collected in an excel spreadsheet and described. Routinely collected CSF biomarkers and radiologic imaging results were recorded whether available. RESULTS: decreased over time despite antiretroviral therapy containing nucleotide reverse transcriptase inhibitors. CONCLUSIONS: In older PLWH cognitive symptoms may represent the onset of AD: a multidisciplinary team may be needed for reaching a likely in vivo diagnosis.