Keratin 17 upregulation promotes cell metastasis and angiogenesis in colon adenocarcinoma
Ran Ji, Yi-Fei Ji, Lin Ma, Sijia Ge, Jing Chen, Shuzhen Wu, Tianxin Huang, Yu Sheng, Liyang Wang, Nan Yi, Zhaoxiu Liu
Abstract
. In addition, we also showed that KRT17 promoted the formation of new blood vessels. Mechanistically, KRT17 could regulate the WNT/β-catenin signaling pathway, and APC may be involved in this process by interacting with KRT17. In summary, these findings suggested that high expression of KRT17 could promote cell metastasis and angiogenesis of colon cancer cells by regulating the WNT/β-catenin signaling pathway. Thus, KRT17 could be a potential therapeutic target for COAD treatment.
Topics & Concepts
Cancer researchMetastasisColorectal cancerWnt signaling pathwayIn vivoAdenocarcinomaAngiogenesisDownregulation and upregulationCancerMedicineSignal transductionChemistryBiologyCell biologyInternal medicineBiochemistryGeneBiotechnologySkin and Cellular Biology ResearchWnt/β-catenin signaling in development and cancerMicrotubule and mitosis dynamics