Transcription factor ELK1 accelerates aerobic glycolysis to enhance osteosarcoma chemoresistance through miR-134/PTBP1 signaling cascade
Qiang Zhang, Jiaqi Wu, Xiangfeng Zhang, Le Cao, Yongping Wu, Xudong Miao
Abstract
by increasing aerobic glycolysis. Additionally, miR-134 inhibited translation of PTBP1. ELK1 bound to miR-134 promoter and inhibited its expression. Overexpressed ELK1 enhanced chemoresistance and increased aerobic glycolysis by downregulating miR-134 and upregulating PTBP1 in DXR-resistant cells. Altogether, the key findings of the present study highlight ELK1/miR-134/PTBP1 signaling cascade as a novel molecular mechanism underlying the acquisition of osteosarcoma chemoresistance.
Topics & Concepts
Anaerobic glycolysisTranscription factorCancer researchGlycolysisOsteosarcomaTranscription (linguistics)ChemistryMedicineMetabolismGeneBiochemistryLinguisticsPhilosophyRNA Research and SplicingRNA modifications and cancerCancer-related molecular mechanisms research