Molecular Editing of Ketones Derived by Pro-aromatic of Dihydroquinazolinones
Xiaoxiao Yang, Xinyue Ma, Chao Shu
Abstract
Ketones represent a vital class of feedstock chemicals in organic synthesis. Researchers have explored a versatile deacylation strategy utilizing ketones as radical precursors, involving activation through condensation with 2-aminobenzamide to form dihydroquinazolinones (DHQZ). This aromatization-driven deconstructive reaction of ketones offers an efficient approach for the selective construction of diverse bonds, including C–H/D, C–C (sp, sp 2, sp 3 ), C–F, C–S/Se, C–N, and C–Si under mild conditions. As a result, ketones have found widespread application in the rapid and efficient assembly of structurally complex molecules. This perspective highlights recent advances in this field, emphasizing product diversity, selectivity, and broad applicability, while providing detailed mechanistic insights.