Neuroprotective potential of choline alfoscerate against β‐amyloid injury: Involvement of neurotrophic signals
Mariano Catanesi, Michele d’Angelo, Andrea Antonosante, Vanessa Castelli, Margherita Alfonsetti, Elisabetta Benedetti, Giovambattista Desideri, Claudio Ferri, Annamaria Cimini
Abstract
Alzheimer's disease represents the most prevalent neurodegeneration worldwide, clinically characterized by cognitive and memory impairment. New therapeutic approaches are extremely important to counteract this disorder. This research is focused on the potential use of choline alfoscerate in preventing neuronal death using in vitro models of Alzheimer's disease, representing the early stage of the disease, treated before or after the insult with glycerylphosphorylcholine. On the light of the results collected, we can postulate that choline alfoscerate, by the activation of the neurotrophin survival pathway, was able to counteract the detrimental effect of β-amyloid in both in vitro models, reducing apoptotic cell death and preserving the neuronal morphology.