Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma
Deeba Ensan, David Smil, Carlos Zepeda‐Velázquez, Dimitrios Panagopoulos, Jong Fu Wong, Eleanor P. Williams, R.J. Adamson, Alex N. Bullock, Taira Kiyota, Ahmed Aman, Owen G Roberts, A.M. Edwards, Jeff A. O’Meara, Methvin Isaac, Rima Al‐awar
Abstract
), which possess high inhibitory activity against ALK2, excellent selectivity, and superior pharmacokinetic profiles.
Topics & Concepts
hERGChemistryBenzamidePharmacologySerineStructure–activity relationshipThreoninePotassium channelCancer researchBiochemistryStereochemistryPhosphorylationIn vitroInternal medicineMedicineBiologyGlioma Diagnosis and TreatmentNeuroblastoma Research and TreatmentsLung Cancer Treatments and Mutations