Disulfiram/copper shows potent cytotoxic effects on myelodysplastic syndromes via inducing Bip-mediated apoptosis and suppressing autophagy
Jie Zha, Silei Bi, Manman Deng, Kai Chen, Pengcheng Shi, Li-Ying Feng, Jixiang He, Xuan Pu, Chengcen Guo, Haijun Zhao, Zhifeng Li, Yirong Jiang, Haihan Song, Bing Xu
Topics & Concepts
DisulfiramCancer researchApoptosisAutophagyIn vivoMyelodysplastic syndromesCell cycle checkpointMedicineCombination therapyPharmacologyCell cycleCytotoxic T cellCyclin D1Downregulation and upregulationIn vitroChemistryInternal medicineBiologyCancerBiochemistryGeneBiotechnologyBone marrowAutophagy in Disease and TherapyAcute Myeloid Leukemia ResearchPhagocytosis and Immune Regulation