Antitumor effects of novel nickel–hydrazone complexes in lung cancer cells
Burak Ay, Onur Şahın, Burcu Saygıdeğer Demir, Yasemin Saygıdeğer, José M. López‐de‐Luzuriaga, Ghodrat Mahmoudi, Damir A. Safin
Abstract
Two novel nickel(<sc>ii</sc>) complexes [NiL<sup>I</sup>]·CH<sub>3</sub>CN (<bold>1</bold>·CH<sub>3</sub>CN) and [Ni(H<sub>2</sub>L<sup>II</sup>)(NCS)<sub>2</sub>]·0.5H<sub>2</sub>O (<bold>2</bold>·0.5H<sub>2</sub>O) were fabricated and in <italic>in vitro</italic> experiments they both showed the dose dependent cytotoxicity and killed A549 lung cancer cells <italic>via</italic> an apoptotic pathway.
Topics & Concepts
ChemistryHydrazoneNickelLung cancerCancer researchStereochemistryCombinatorial chemistryInternal medicineOrganic chemistryBiologyMedicineMetal complexes synthesis and propertiesFerrocene Chemistry and ApplicationsMetal-Organic Frameworks: Synthesis and Applications