NBE-Controlled Palladium-Catalyzed Intermolecular Selective C–H Silylation of Boronic Acids
Wenguang Li, Yongqi Yu, Xu Zhang, Chunyan Zhang, Ming Chen, Ting Li
Abstract
An efficient palladium-catalyzed intermolecular selective C–H silylation of boronic acids is described. The combination of palladium catalyst with copper oxidant enables ortho -selective C–H silylation by employing hexamethyldisilane as the trimethylsilyl source, which relies on the control of NBE derivatives as a switch, thus providing straightforward access to divergent organosilicon compounds.
Topics & Concepts
SilylationOrganosiliconPalladiumCatalysisChemistryTrimethylsilylIntermolecular forceOrganic chemistryCombinatorial chemistryMoleculeCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsOrganoboron and organosilicon chemistry