The carbonyl nucleobase adduct M3Ade is a potent antigen for adaptive polyclonal MR1-restricted T cells
Andrew Chancellor, Daniel Constantin, Giuliano Berloffa, Qinmei Yang, Vladimir Nosi, José Pedro Loureiro, Rodrigo Colombo, Roman P. Jakob, Daniel Joss, Michael Pfeffer, Giulia De Simone, Aurelia Morabito, Verena Schaefer, Alessandro Vacchini, Laura Brunelli, Daniela Montagna, Markus H. Heim, Alfred Zippelius, Enrico Davoli, Daniel Häußinger, Timm Maier, Lucia Mori, Gennaro De Libero
Abstract
Ade is an MR1-presented self-metabolite that enables stimulation and tracking of human-MR1T cells from blood and tissue, aiding our understanding of their roles in health and disease.
Topics & Concepts
Polyclonal antibodiesAdductBiologyNucleobaseAntigenMolecular biologyBiochemistryGeneticsDNAChemistryOrganic chemistryImmune Cell Function and InteractionImmunotherapy and Immune ResponsesAdenosine and Purinergic Signaling