MAP Kinase-Mediated Activation of RSK1 and MK2 Substrate Kinases
Péter Sok, Gergő Gógl, Ganesan Senthil Kumar, Anita Alexa, Neha Singh, Klára Kirsch, Anna Sebő, László Drahos, Zoltán Gáspári, Wolfgang Peti, Attila Reményi
Topics & Concepts
KinaseCell biologyPhosphorylationp38 mitogen-activated protein kinasesAllosteric regulationMitogen-activated protein kinaseMAPK/ERK pathwaySubstrate-level phosphorylationProtein kinase domainSignal transductionBiologyChemistryProtein-Serine-Threonine KinasesCell signalingProtein kinase ABiochemistryEnzymeMutantGeneMelanoma and MAPK PathwaysProtein Kinase Regulation and GTPase SignalingQuinazolinone synthesis and applications