Catalytic photooxygenation degrades brain Aβ in vivo
Nozomu Nagashima, Shuta Ozawa, Masahiro Furuta, Miku Oi, Yukiko Hori, Taisuke Tomita, Youhei Sohma, Motomu Kanai
Abstract
that permeates the blood-brain barrier and selectively and directly degrades an extracellular Alzheimer's disease-related undruggable protein, amyloid-β protein (Aβ). Key was the identification of a compact but orange color visible light-activatable chemical catalyst whose activity can be switched on/off according to its molecular mobility, thereby ensuring high selectivity for aggregated Aβ. Chemical catalyst-promoted protein degradation can be applied universally for attenuating extracellular amyloids and various pathogenic proteins and is thus a new entry to induced protein degradation strategies.
Topics & Concepts
PhotooxygenationIn vivoCatalysisChemistrySinglet oxygenBiologyBiochemistryOrganic chemistryOxygenBiotechnologyNeuroscience and Neuropharmacology ResearchRetinal Development and DisordersAdvanced Fluorescence Microscopy Techniques