An MRI-visible immunoadjuvant based on hollow Gd<sub>2</sub>O<sub>3</sub> nanospheres for cancer immunotherapy
Xia Li, Xiupeng Wang, Atsuo Ito
Abstract
Hollow Gd2O3 nanospheres significantly promote the cellular uptake of a tumor antigen by antigen presenting cells, exhibit pH-dependent alteration of the MR signal intensity and markedly enhance the antitumor immunity. Hollow Gd2O3 nanospheres are promising as magnetic resonance imaging (MRI)-visible cancer immunoadjuvants for cancer immunotherapy.
Topics & Concepts
ImmunoadjuvantImmunotherapyCancer immunotherapyAntigenChemistryNanocrystalCancer researchCancerMaterials scienceNanotechnologyMedicineImmunologyInternal medicineNanoplatforms for cancer theranosticsAdvanced biosensing and bioanalysis techniquesNanoparticle-Based Drug Delivery