Mitochondrial entry gate as regulatory hub
Fabian den Brave, Nikolaus Pfanner, Thomas Becker
Abstract
Mitochondria import 1000-1300 different precursor proteins from the cytosol. The main mitochondrial entry gate is formed by the translocase of the outer membrane (TOM complex). Molecular coupling and modification of TOM subunits control and modulate protein import in response to cellular signaling. The TOM complex functions as regulatory hub to integrate mitochondrial protein biogenesis and quality control into the cellular proteostasis network.
Topics & Concepts
ProteostasisCell biologyTranslocase of the inner membraneMitochondrionMitochondrial biogenesisCytosolTranslocaseTranslocase of the outer membraneBiologyMitochondrial carrierInner mitochondrial membraneATP–ADP translocaseChemistryMitochondrial membrane transport proteinBiochemistryBacterial outer membraneGeneEnzymeChromosomal translocationEscherichia coliMitochondrial Function and PathologyATP Synthase and ATPases ResearchMetabolism and Genetic Disorders