Electrochemical Decarboxylative Coupling of <i>N</i>‐Substituted Glycines under Air: Access to C3‐Aminomethylated Imidazo[1,2‐<i>a</i>]pyridines
Sifeng Li, Xingchen Li, Xingchen Li, Taimin Wang, Qingjing Yang, Zijun Ouyang, Jieyu Chen, Hongbin Zhai, Xiao Li, Xiao Li, Bin Cheng
Abstract
Abstract An electrochemical decarboxylative aminomethylation reaction of imidazo[1,2‐ a ]pyridines with various N ‐substituted glycines in acetonitrile at room temperature has been described. The reaction could be conducted under light‐free, catalyst‐free, oxidant‐free, and air conditions, affording the C3‐aminomethylated imidazo[1,2‐ a ]pyridines in good to high yields. Remarkably, N ‐aryl, N , N ‐dialkyl, and N ‐alkyl‐ N ‐aryl glycines are all well‐tolerated in this easily handled protocol, which further expands the chemical space of bioactive imidazo[1,2‐ a ]pyridine derivatives. magnified image
Topics & Concepts
ChemistryArylAcetonitrileElectrochemistryAlkylDecarboxylationPyridineCatalysisCombinatorial chemistryMedicinal chemistryOrganic chemistryPhysical chemistryElectrodeRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsFluorine in Organic Chemistry