Desolvation induced crystal jumping: reversible hydration and dehydration of a spironolactone–saccharin cocrystal with water as the jumping-mate
Yifu Chen, Bo Jing, Zewei Chang, Junbo Gong
Abstract
We present a spironolactone–saccharin cocrystal hydrate as the first example of a crystal that jumps without changes in either the lattice parameter or the molecular conformation to highlight the unique advantages of the jumping-mate strategy.
Topics & Concepts
JumpingCocrystalHydrateDehydrationChemistrySaccharinCrystal (programming language)SpironolactoneCrystallographyMaterials scienceHydrogen bondOrganic chemistryComputer scienceMoleculeBiochemistryBiologyEndocrinologyProgramming languagePhysiologyAldosteroneCrystallography and molecular interactionsSpectroscopy and Quantum Chemical StudiesCrystallization and Solubility Studies