Nerve growth factor activates autophagy in Schwann cells to enhance myelin debris clearance and to expedite nerve regeneration
Rui Li, Duohui Li, Chengbiao Wu, Libing Ye, Yanqing Wu, Yuan Yuan, Shengnan Yang, Ling Xie, Yuqin Mao, Ting Jiang, Yiyang Li, Jian Wang, Hongyu Zhang, Xiaokun Li, Jian Xiao
Abstract
/AMPK/mTOR axis. Our studies thus provide strong support that NGF may serve as a powerful pharmacological therapy for peripheral nerve injuries.
Topics & Concepts
Regeneration (biology)AutophagyNerve growth factorMyelinNerve guidance conduitSchwann cellCell biologySciatic nerveMyelin sheathNeuroscienceAnatomyChemistryPathologyMedicineBiologyInternal medicineCentral nervous systemReceptorApoptosisBiochemistryNerve injury and regenerationAutophagy in Disease and TherapyNeurogenesis and neuroplasticity mechanisms