<p>Onco-Metabolic Surgery: A Combined Approach to Gastric Cancer and Hypertension</p>
Dong Peng, Yu-Xi Cheng, Wei Tao, Yingying Zou, Kun Qian, Wei Zhang
Abstract
Purpose: The purpose of this study was to explore the changes in blood pressure in patients with concurrent gastric cancer and hypertension after gastrectomy, and to identify the factors that affect the changes in blood pressure. Materials and Methods: Patients with concurrent gastric cancer and hypertension who underwent gastrectomy were retrospectively analyzed from January 2013 to December 2018. The pre- and 6-month postoperative medical records were compared. Predictors for the remission of hypertension were analyzed. Results: A total of 143 patients with concurrent gastric cancer and hypertension were included in this study. The number of patients with complete remission, partial remission and no remission were 67 (46.9%), 12 (8.4%) and 64 (44.7%), respectively. The average of weight and BMI (body mass index) before gastrectomy were 63.0 ± 9.7 kg and 23.4 ± 2.9 kg/m 2 , respectively, which were significantly higher than those 6-month postgastrectomy: 54.8 ± 9.8 kg and 20.4 ± 3.1 kg/m 2 , respectively (p< 0.001). The average number of antihypertensive medications before gastrectomy was 1.5 ± 0.6, while it was 0.8 ± 0.8 6-month postgastrectomy (p< 0.001). Age (p< 0.05) and the surgical techniques used (p< 0.05) were significantly different between partial remission and no remission patients. Furthermore, age (p< 0.05) and the surgical techniques used (p< 0.05) were significantly different between complete remission and no remission patients. Age (p< 0.05, odds ratio =0.933, 95% CI=0.890– 0.978) and the surgical techniques used (p< 0.05, odds ratio =2.749, 95% CI=1.132– 6.677) are predictors for remission of hypertension. Conclusion: Total gastrectomy is an onco-metabolic surgery that can cure younger patients with concurrent gastric cancer and hypertension. Age and the surgical techniques used can predict the remission of hypertension 6 months after gastrectomy. Keywords: gastric cancer, age, hypertension, gastrectomy, remission