Organelle-targeting activity-based hemicyanine derivatives for enhanced and selective type-I photodynamic therapy under hypoxia conditions
Musa Dirak, Ayca Saymaz, Alperen Acari, Yunus Akkoç, Haluk Samet Kocak, Cansu M. Yenici, Devrim Gözüaçık, Hande Gündüz, Safacan Kölemen
Abstract
Two organelle-targeted and hydrogen sulfide responsive type-I photodynamic therapy agents are developed for selective and effective treatment of hypoxic cancer cells.
Topics & Concepts
Photodynamic therapyHypoxia (environmental)OrganelleCancer researchChemistryCombinatorial chemistryPharmacologyBiochemistryMedicineOrganic chemistryOxygenPhotodynamic Therapy Research StudiesNanoplatforms for cancer theranosticsCancer, Hypoxia, and Metabolism