mTOR signaling regulates multiple metabolic pathways in human lung fibroblasts after TGF-β and in pulmonary fibrosis
Kun Woo D Shin, Volkan Atalay, Rengül Çetin-Atalay, Erin O’Leary, Mariel E Glass, J. Szafran, Parker S. Woods, Angelo Y. Meliton, O.R. Shamaa, Yufeng Tian, Gökhan M. Mutlu, Robert B. Hamanaka
2025American Journal of Physiology-Lung Cellular and Molecular Physiology14 citationsDOIOpen Access PDF
Abstract
Here, we used transcriptomic and metabolomic approaches to develop a more complete understanding of the role that mTOR, and its downstream effector ATF4, play in promoting metabolic reprogramming in lung fibroblasts. We identify novel metabolic pathways that may promote pathologic phenotypes, and we provide evidence from single-cell RNA-seq datasets that similar metabolic reprogramming occurs in patient lungs.
Topics & Concepts
PI3K/AKT/mTOR pathwayATF4mTORC1BiologyIntegrated stress responseCell biologyDownregulation and upregulationmTORC2Cancer researchSignal transductionBiochemistryUnfolded protein responseMessenger RNAEndoplasmic reticulumTranslation (biology)GeneMedical Imaging and Pathology StudiesInterstitial Lung Diseases and Idiopathic Pulmonary FibrosisRenal and related cancers