Development of gum odina‐gelatin based antimicrobial loaded biodegradable spongy scaffold: A promising wound care tool
Shilpa Das, Arnab De, Bhaskar Das, Biswajit Mukherjee, Amalesh Samanta
Abstract
Abstract The present study focuses on development of HPMC K100M reinforced antimicrobial loaded spongy biodegradable wound dressing scaffold by blending gum odina (GO) and gelatin (G) which has not been explored so far. All the prepared formulations by varying GO‐HPMC K100M: G are subjected to physicochemical evaluations (visual appearance, swelling study, biodegradability, drug loading, and drug release). F3B (GO‐HPMC K100M: G = 1:1, blank) and F3D (GO‐HPMC K100M: G = 1:1, drug loaded) are optimized and selected for further evaluations. Controlled degradation and sustained release of impregnated drug molecules from F3D may influence the antimicrobial efficacy. A satisfactory result of protein adsorption on the surface of F3B and F3D (almost 24%) can be an important event for being a biomaterial. The safe value of hemolytic potentiality (approximately 4%) may consider as biocompatible in nature. Furthermore, upon other characterizations F3B and F3D can be considered as an excellent potential candidate for biomedical application.