Design, synthesis, and Structure–Activity Relationships (SAR) of 3-vinylindazole derivatives as new selective tropomyosin receptor kinases (Trk) inhibitors
Yunxin Duan, Jie Wang, Sihua Zhu, Zhengchao Tu, Zhang Zhang, Shingpan Chan, Ke Ding
Topics & Concepts
Trk receptorTropomyosin receptor kinase AChemistryKinaseTyrosine kinaseReceptor tyrosine kinaseIC50PharmacologyLead compoundPotentiatorTropomyosin receptor kinase BReceptorNeurotrophinBiochemistryIn vitroBiologyNeurotrophic factorsCancer Mechanisms and TherapyPI3K/AKT/mTOR signaling in cancerHistone Deacetylase Inhibitors Research