Human Milk Oligosaccharide Utilization in Intestinal Bifidobacteria Is Governed by Global Transcriptional Regulator NagR
Aleksandr A. Arzamasov, Aruto Nakajima, Mikiyasu Sakanaka, Miriam N. Ojima, Takane Katayama, Dmitry A. Rodionov, Andrei L. Osterman
Abstract
The predominance of bifidobacteria in the gut of breastfed infants is attributed to the ability of these bacteria to metabolize human milk oligosaccharides (HMOs). Thus, individual HMOs such as lacto- N -tetraose (LNT) and lacto- N -neotetraose (LNnT) are considered promising prebiotics that would stimulate the growth of bifidobacteria and confer multiple health benefits to preterm and malnourished children suffering from impaired (stunted) gut microbiota development.
Topics & Concepts
RegulatorOligosaccharideBifidobacteriumFood scienceBiologyMicrobiologyChemistryBiochemistryLactobacillusGeneFermentationInfant Nutrition and HealthDigestive system and related healthPediatric Hepatobiliary Diseases and Treatments