Supramolecular nanoprodrug based on a chloride channel blocker and glycosylated pillar[5]arenes for targeted chemoresistance cancer therapy
Ke Yang, Ke Ma, Manman Yang, Yinghua Lv, Yuxin Pei, Zhichao Pei
Abstract
studies revealed that this supramolecular nanoprodrug can overcome drug resistance through inhibiting chloride channels as well as inhibiting the migration of HepG2/ADR cells. This strategy can therefore achieve enhanced potency in chemotherapy through reverse chemoresistance.
Topics & Concepts
PillarSupramolecular chemistryCancerCancer therapyChemistryChlorideCombinatorial chemistryCancer researchPharmacologyNanotechnologyMedicineInternal medicineOrganic chemistryMoleculeMaterials scienceStructural engineeringEngineeringRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniquesSupramolecular Chemistry and Complexes