Proteomic Architecture of Valvular Extracellular Matrix
Rihab Bouchareb, Sandra Guauque-Olarte, Justin M. Snider, Devyn Zaminski, Anelechi Anyanwu, Paul Stelzer, Djamel Lebeche
Abstract
This study analyzed the expression of extracellular matrix (ECM) proteins during aortic valve calcification with mass spectrometry, and further validated in an independent human cohort using RNAseq data. The study reveals that valve calcification is associated with significant disruption in ECM and metabolic pathways, and highlights a strong connection between metabolic markers and ECM remodeling. It also identifies FNDC1 and MXRA5 as novel ECM biomarkers in calcified valves, electing them as potential targets in the development and progression of aortic stenosis.
Topics & Concepts
Extracellular matrixCalcificationCell biologyExtracellularAortic valveAortic valve stenosisChemistryCardiologyInternal medicineMedicinePathologyBiologyCardiac Valve Diseases and TreatmentsProtease and Inhibitor MechanismsCalpain Protease Function and Regulation