YTHDF2 Is Downregulated in Response to Host Shutoff Induced by DNA Virus Infection and Regulates Interferon-Stimulated Gene Expression
Charles R. Hesser, Derek Walsh
Abstract
A reader proteins, in particular YTHDF2, in response to shutoff of protein synthesis upon infection with the large DNA viruses, vaccinia virus (VacV), or herpes simplex virus type 1. We further reveal that YTHDF2 downregulation also occurs as part of the host protein kinase R response to a VacV shutoff mutant and that this downregulation of YTHDF family members functions to enhance interferon-stimulated gene expression to create an antiviral state.
Topics & Concepts
BiologyInterferonGeneDNARNAViral infectionGene expressionVirusHost (biology)VirologyCell biologyGeneticsMolecular biologyRNA modifications and cancerRNA Research and SplicingCancer-related molecular mechanisms research