Copper-Catalyzed Enaminone C(sp<sup>2</sup>)–N Bond Phosphonation for Stereoselective Synthesis of Alkenylphosphonates
Ting Liu, Wei Li, Baoli Zhao, Yunyun Liu, Jie‐Ping Wan
Abstract
A direct enaminone C–N bond coupling functionalization that generates a new C–P bond using dialkyl phosphonate for the efficient and stereoselective synthesis of (E)-alkenylphosphonates is reported. The reactions toward target products proceed well with a broad scope, disclosing a valuable new synthetic application of enaminones by the interesting C(sp2)–N bond elaboration.
Topics & Concepts
StereoselectivitySurface modificationChemistryCatalysisPhosphonateCopperCombinatorial chemistryOrganic synthesisFormal synthesisStereochemistryOrganic chemistryPhysical chemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsSulfur-Based Synthesis Techniques