Comparing the Characteristics of Microglia Preparations Generated Using Different Human iPSC-Based Differentiation Methods to Model Neurodegenerative Diseases
Ye Man Tang, Nisha S. Pulimood, Stefano Stifani
Abstract
regionally distinct microglia subtypes, specifically white-matter and gray-matter microglia. These findings highlight the need to better characterize the subtype composition of each microglia preparation prior to its use to model neurodegenerative diseases.
Topics & Concepts
MicrogliaInduced pluripotent stem cellNeuroscienceBiologyNeuroinflammationTranscriptomeAmyotrophic lateral sclerosisHuman brainCentral nervous systemMultiple sclerosisDiseaseMedicinePathologyImmunologyInflammationGene expressionEmbryonic stem cellGeneGeneticsNeuroinflammation and Neurodegeneration MechanismsNuclear Receptors and SignalingImmune cells in cancer