CDC20 is a novel biomarker for improved clinical predictions in epithelial ovarian cancer.
Xiaoxue Xi, Tianyue Cao, Yonghong Qian, Huiling Wang, Songwen Ju, Youguo Chen, Ting Chen, Jian Yang, Biaoquan Liang, Shunyu Hou
Abstract
expression decreased. In conclusion, CDC20 is likely a key biomarker of EOC and may act as an upstream regulator of SOX2 to mediate the SOX2 signaling in the progression of EOC. Future application of CDC20 analysis to early detection may improve prognosis, and it has the potential to be a therapeutic target.
Topics & Concepts
Cancer researchCell cycleBiologyOvarian cancerSmall hairpin RNAKEGGSOX2Wnt signaling pathwayHMGA2Gene knockdownCancerGeneOncologymicroRNAMedicineGene expressionTranscription factorGeneticsTranscriptomeRNA modifications and cancerCancer Mechanisms and TherapyOvarian cancer diagnosis and treatment