Insulin Adsorption onto PE and PVC Tubings
Nicolas Tokhadzé, Meriem Sahnoune, Julien Devémy, Alain Dequidt, Florent Goujon, Philip Chennell, Valérie Sautou, Patrice Malfreyt
Abstract
We investigate the adsorption of insulin onto PE and PVC materials by using HPLC measurements and computer simulations. We interpret the experiments by calculating the Gibbs free energy profiles during the adsorption process. The values of free energy of adsorption show a good agreement with the experimental measurements. The adsorption of insulin onto the different materials is characterized through the conformational changes with respect to its conformation in water and the interfacial regions, which are described by specific arrangements of polymer chains, water, insulin, and plasticizer molecules.
Topics & Concepts
AdsorptionGibbs free energyPolymerChemical engineeringPlasticizerMoleculeMaterials scienceInsulinProcess (computing)ThermodynamicsChemistryChromatographyPhysical chemistryOrganic chemistryComputer scienceOperating systemPhysicsMedicineEngineeringEndocrinologyMicrofluidic and Capillary Electrophoresis ApplicationsMembrane Separation and Gas TransportMembrane Separation Technologies