Palladium-catalyzed asymmetric allylic amination of a vinylethylene carbonate with N-heteroaromatics
Chao Xia, Dong‐Chao Wang, Gui‐Rong Qu, Hai‐Ming Guo
Abstract
Highly enantioselective allylic amination of a vinylethylene carbonate with N-heteroaromatics is enabled by asymmetric palladium catalysis for the synthesis of chiral acyclic nucleosides and isonucleosides.
Topics & Concepts
AminationChemistryAllylic rearrangementEnantioselective synthesisPalladiumCatalysisCarbonateOrganic chemistryCombinatorial chemistryMedicinal chemistryAsymmetric Synthesis and CatalysisAsymmetric Hydrogenation and CatalysisSynthetic Organic Chemistry Methods