Increase in <i>Kelch 13</i> Polymorphisms in <i>Plasmodium falciparum</i>, Southern Rwanda
Clara Bergmann, Welmoed van Loon, Felix Habarugira, Costanza Tacoli, Julia C. Jäger, Darius Savelsberg, Fabian Nshimiyimana, Elias Rwamugema, Djibril Mbarushimana, Jules Ndoli, Augustin Sendegeya, Claude Bayingana, Frank P. Mockenhaupt
Abstract
Artemisinin resistance in Plasmodium falciparum is associated with nonsynonymous mutations in the Kelch 13 (K13) propeller domain. We found that 12.1% (8/66) of clinical P. falciparum isolates from Huye district, Rwanda, exhibited K13 mutations, including R561H, a validated resistance marker. K13 mutations appear to be increasing in this region.
Topics & Concepts
Plasmodium falciparumNonsynonymous substitutionBiologyArtemisininMalariaVirologyGeneticsGeneImmunologyGenomeMalaria Research and ControlDrug-Induced Hepatotoxicity and ProtectionMosquito-borne diseases and control