Allosteric control of type I-A CRISPR-Cas3 complexes and establishment as effective nucleic acid detection and human genome editing tools
Chunyi Hu, Dongchun Ni, Ki Hyun Nam, Sonali Majumdar, Justin McLean, Henning Stahlberg, Michael P. Terns, Ailong Ke
Topics & Concepts
BiologyCRISPRGenome editingPyrococcus furiosusEffectorNucleaseDNARNAComputational biologyNucleic acidGeneticsMolecular biologyCell biologyGeneArchaeaCRISPR and Genetic EngineeringRNA and protein synthesis mechanismsRNA regulation and disease