Retinoic Acid Increases Cellular Cholesterol in Leishmania donovani-Infected Macrophages in an mTOR-Independent Manner
Satya Prakash, Ambak Kumar
Abstract
synthesis of sterol. We have already shown that RA regulates cellular cholesterol levels associated with an efficient immune response. A deficiency of retinoic acid (RA) favors the parasite in Leishmania donovani-infected macrophages by downregulating the immune response. In the present work, we observed that RA restores cellular cholesterol levels in Leishmania donovani-infected macrophages. This study proposes using RA as an immune potentiator along with standard therapy.
Topics & Concepts
Leishmania donovaniABCA1CholesterolBiologymTORC1mTORC2Sterol regulatory element-binding proteinMechanistic target of rapamycinPI3K/AKT/mTOR pathwayInternalizationCell biologyBiochemistrySterolVisceral leishmaniasisReceptorTransporterSignal transductionImmunologyLeishmaniasisGeneResearch on Leishmaniasis StudiesTrypanosoma species research and implicationsCholesterol and Lipid Metabolism