miR-495 Regulates Cellular Reactive Oxygen Species Levels by Targeting <i>sod2</i> To Inhibit Intracellular Survival of Mycobacterium tuberculosis in Macrophages
Xuanxiu Ren, Wenqi Dong, Jiajia Feng, Pei Li, Yucheng Zheng, Gaoyan Wang, Wenjia Lu, Xiangru Wang, Huanchun Chen, Chen Tan
Abstract
expression by miR-495 to promote the intracellular survival of BCG/H37Rv through a decline in ROS levels. This study provides a theoretical basis for developing new drug targets and treating tuberculosis.
Topics & Concepts
IntracellularMycobacterium tuberculosisDownregulation and upregulationIntracellular parasiteTuberculosisBiologyMicrobiologyPathogenesisReactive oxygen speciesDiseaseMycobacteriumInfectious disease (medical specialty)ImmunologyBacteriaCell survivalVirologyCellCytotoxicityDrug resistanceCell cultureMacrophageTuberculosis Research and EpidemiologyMicroRNA in disease regulationImmune responses and vaccinations