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A synthetic small molecule stalls pre-mRNA splicing by promoting an early-stage U2AF2-RNA complex

Rakesh Chatrikhi, Callen F. Feeney, Mary J. Pulvino, Georgios Alachouzos, Andrew J. MacRae, Zackary Falls, Sumit Rai, William W. Brennessel, Jermaine L. Jenkins, Matthew J. Walter, Timothy A. Graubert, Ram Samudrala, Melissa S. Jurica, Alison J. Frontier, Clara L. Kielkopf

2021Cell chemical biology38 citationsDOIOpen Access PDF

Topics & Concepts

SpliceosomeRNA splicingRNAChemistrySmall moleculeCell biologyMessenger RNABiologyComputational biologyBiochemistryGeneRNA Research and SplicingRNA and protein synthesis mechanismsRNA modifications and cancer
A synthetic small molecule stalls pre-mRNA splicing by promoting an early-stage U2AF2-RNA complex | Litcius