A synthetic small molecule stalls pre-mRNA splicing by promoting an early-stage U2AF2-RNA complex
Rakesh Chatrikhi, Callen F. Feeney, Mary J. Pulvino, Georgios Alachouzos, Andrew J. MacRae, Zackary Falls, Sumit Rai, William W. Brennessel, Jermaine L. Jenkins, Matthew J. Walter, Timothy A. Graubert, Ram Samudrala, Melissa S. Jurica, Alison J. Frontier, Clara L. Kielkopf
Topics & Concepts
SpliceosomeRNA splicingRNAChemistrySmall moleculeCell biologyMessenger RNABiologyComputational biologyBiochemistryGeneRNA Research and SplicingRNA and protein synthesis mechanismsRNA modifications and cancer