Chemoselective synthesis of 5,4′-imidazolinyl spirobarbiturates <i>via</i> NBS-promoted cyclization of unsaturated barbiturates and amidines
Hui Xu, Ronglu Huang, Shu Zhu, Ran Hong, Ze Zhang
Abstract
A selective cyclization of unsaturated barbiturates and amidines promoted by N-bromosuccinimide has been successfully developed to afford a vast variety of 5,4'-imidazolinyl spirobarbiturates in moderate to good yields. The present protocol features broad substrate scope, facile work-up procedure and mild reaction conditions, providing a novel strategy for the highly selective and efficient construction of structurally diverse spiroimidazolines.
Topics & Concepts
ChemistryCombinatorial chemistrySubstrate (aquarium)Scope (computer science)Reaction conditionsOrganic chemistryCatalysisProgramming languageGeologyComputer scienceOceanographyCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsChemical Synthesis and Analysis