Different Lewis Acid Promotor-Steered Highly Regioselective Phosphorylation of Tertiary Enamides
Wenzhong Li, Ran Shi, Xuesi Zhang, Sen Chen, Yu Wang, Mengqi Wang, Bin Yang, Jiazhu Li, Xin‐Ming Xu
Abstract
Different Lewis acid promotor-steered highly regioselective phosphorylation of tertiary enamides with diverse H-phosphonates or H-phosphine oxides was developed. Under the catalysis of iron salt, the phosphonyl group was introduced into the α-position of tertiary enamides, affording various α-phosphorylated amides in high efficiency. On the other hand, the β-phosphorylated tertiary enamides were efficiently obtained as the products in the presence of manganese(III) acetylacetonate.
Topics & Concepts
RegioselectivityChemistryPhosphinePhosphorylationLewis acids and basesManganeseCatalysisPromoterCombinatorial chemistryOrganic chemistryBiochemistryGeneGene expressionOrganophosphorus compounds synthesisChemical Synthesis and AnalysisAsymmetric Hydrogenation and Catalysis