Optimized Synthesis of New Thiosemicarbazide Derivatives with Tuberculostatic Activity
Corina Popovici, Cristina-Maria Pavel, Valeriu Şunel, Corina Cheptea, Dan Gheorghe Dimitriu, Dana Ortansa Dorohoi, Diana David, Valentina Cloşca, Marcel Popa
Abstract
Original results are presented in the field of research that addresses the extension of the reaction of residue of acyl-thiosemicarbazide fixation on the structure of 5-nitrobenzimidazole by a sulphonic group. The aim of the study is the increase of new thiosemicarbazide derivatives’ applicative potential in the field of biochemistry, with a wide range of medical applications. The newly obtained compounds were characterized by using elemental analysis and spectral analysis (FT-IR and 1H NMR). A study regarding the optimization of the chemical reactions was made. The performed in vitro biological tests confirmed the tuberculostatic activity of three newly obtained compounds against Mycobacterium tuberculosis.