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Identification of novel and potent PROTACs targeting FAK for non-small cell lung cancer: Design, synthesis, and biological study

Yin Sun, Ruifeng Wang, Yu Sun, Lin Wang, Yanli Xue, Jingkai Wang, Tianxiao Wu, Wenbo Yin, Qiaohua Qin, Yixiang Sun, Dongmei Zhao, Maosheng Cheng

2022European Journal of Medicinal Chemistry24 citationsDOIOpen Access PDF

Topics & Concepts

Focal adhesionChemistryCell biologyTyrosine kinaseAngiogenesisKinaseCancer researchSignal transductionBiochemistryBiologyProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysPeptidase Inhibition and Analysis
Identification of novel and potent PROTACs targeting FAK for non-small cell lung cancer: Design, synthesis, and biological study | Litcius