Mesojunction-Based Design Paradigm of Structural DNA Nanotechnology
Tianqi Wang, Tanxi Bai, Zhenyu Tan, Yoel P. Ohayon, Ruojie Sha, Simon Vecchioni, Nadrian C. Seeman, Bryan Wei
Abstract
Mesojunctions were introduced as a basic type of crossover configuration in the early development of structural DNA nanotechnology. However, the investigations of self-assembly from multiple mesojunction complexes have been overlooked in comparison to their counterparts based on regular junctions. In this work, we designed standardized component strands for the construction of complex mesojunction lattices. Three typical mesojunction configurations with three and four arms were showcased in the self-assembly of 1-, 2-, and 3-dimensional lattices constructed from both a scaffold-free tiling approach and a scaffolded origami approach.
Topics & Concepts
NanotechnologyDNA nanotechnologyChemistryDNA origamiSelf-assemblyComponent (thermodynamics)ScaffoldDesign elements and principlesDNAPhysicsSystems engineeringComputer scienceEngineeringMaterials scienceBiochemistryThermodynamicsDatabaseAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene DeliveryDNA and Nucleic Acid Chemistry