Matrix stiffness regulates the tight junction phenotypes and local barrier properties in tricellular regions in an iPSC-derived BBB model
Li Yan, Cole W. Dwiggins, Rebecca A. Moriarty, Jae Woo Jung, Udit Gupta, Ken D. Brandon, Kimberly M. Stroka
Topics & Concepts
Blood–brain barrierTight junctionExtracellular matrixBarrier functionCell biologyMaterials scienceInduced pluripotent stem cellEndothelial stem cellStiffnessBiophysicsBiologyNeuroscienceIn vitroEmbryonic stem cellCentral nervous systemBiochemistryGeneComposite materialBarrier Structure and Function StudiesMRI in cancer diagnosisAdvanced Neuroimaging Techniques and Applications