Intranasal delivery of phenytoin-loaded nanoparticles to the brain suppresses pentylenetetrazol-induced generalized tonic clonic seizures in an epilepsy mouse model
Amal Yousfan, Noelia Rubio, M. Al‐Ali, Abdul Hakim Nattouf, Houmam Kafa
Abstract
In this work we describe the preparation and characterization of lecithin–chitosan nanoparticles (L 10 C i + ), and investigate their ability to deliver the anti-epileptic drug phenytoin (PHT) to mouse brain following intranasal (IN) administration.
Topics & Concepts
PentylenetetrazolNasal administrationPhenytoinPharmacologyEpilepsySystemic administrationRoute of administrationChemistryDrug deliveryMedicineSpleenAnticonvulsantAnesthesiaInternal medicineIn vivoBiologyPsychiatryOrganic chemistryBiotechnologyAdvanced Drug Delivery SystemsEpilepsy research and treatmentDrug Transport and Resistance Mechanisms