Glomerular Function and Urinary Biomarker Changes between Vancomycin and Vancomycin plus Piperacillin-Tazobactam in a Translational Rat Model
Jack Chang, Gwendolyn Pais, Kimberly Valdez, Sylwia Marianski, Erin F. Barreto, Marc H. Scheetz
Abstract
= 0.036). Kidney function decline and increased KIM-1 were observed among rats that received VAN only but not those that received TZP or VAN + TZP. The addition of TZP to VAN does not worsen kidney function or injury in our translational rat model.
Topics & Concepts
Renal functionUrologyMedicineNephrotoxicityUrinary systemVancomycinConfidence intervalAcute kidney injuryInternal medicineKidneyStaphylococcus aureusBacteriaGeneticsBiologySepsis Diagnosis and TreatmentChronic Kidney Disease and DiabetesAcute Kidney Injury Research