Building ubiquitination machineries: E3 ligase multi-subunit assembly and substrate targeting by PROTACs and molecular glues
Sarath Ramachandran, Alessio Ciulli
Topics & Concepts
Ubiquitin ligaseDegronUbiquitin-Protein LigasesUbiquitinDNA ligaseProtein subunitCullinCell biologyBiologyTernary complexBiochemistryComputational biologyEnzymeGeneProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysPeptidase Inhibition and Analysis