Heparin-based, injectable microcarriers for controlled delivery of interleukin-13 to the brain
Lucas Schirmer, Chloé Hoornaert, Debbie Le Blon, Dimitri Eigel, Cátia Neto, Mark Gumbleton, Petra B. Welzel, Anne Rosser, Carsten Werner, Peter Ponsaerts, Ben Newland
Abstract
Interleukin-13 (IL-13) drives cells of myeloid origin towards a more anti-inflammatory phenotype, but delivery to the brain remains problematic. Herein, we show that heparin-based cryogel microcarriers load high amounts of IL-13, releasing it slowly. Intra-striatal injection of loaded microcarriers caused local up-regulation of ARG1 in myeloid cells for pro-regenerative immunomodulation in the brain.
Topics & Concepts
HeparinMicrocarrierCytokineChemistryPharmacologyMedicineImmunologyBiochemistryCellGalectins and Cancer BiologyGlycosylation and Glycoproteins ResearchNerve injury and regeneration